Tütün Ufuk, Ulus A Tulga, Aksöyek Aysen I, Hizarci Mustafa, Kaplan Sadi, Erbas Sakine, Köse Kenan, Katircioglu S Fehmi, Kutsal Ali
Department of Cardiovascular Surgery at Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey.
J Heart Valve Dis. 2003 Sep;12(5):585-91.
The study aim was to investigate the long-term efficacy of closed mitral valvotomy (CMV).
Data obtained over a 36-year period from 1,134 patients who underwent CMV were analyzed. The analysis was carried out retrospectively from hospital records, with follow up examinations being conducted mainly at the outpatient clinic.
In-hospital mortality (< or = 30 days after surgery) was 0.4% (n = 5, all closed procedures). Cardiac failure was the main cause of early death, and postoperative peripheral embolism occurred in five cases (0.5%). Freedom from thromboembolism was 99.0 +/- 0.5% at 36 years. Operative results were satisfactory in most patients, and severe mitral incompetence was seen only in three cases. Post-valvotomy mitral regurgitation occurred in 88 patients (7.7%) during the first year after CMV. Reoperation was performed in 500 patients (44.1%). The mean interval between CMV and reoperation was 141.1 +/- 80.8 months (range: 1-436 months). Fourteen patients were reoperated on for mitral regurgitation, 485 for mitral restenosis, and five for mixed mitral valve disease (stenosis and regurgitation). Freedom from reoperation after CMV was 81.4 +/- 1.3% at 10 years, 16.4 +/- 2.1% at 20 years, 3.1 +/- 1.2% at 20 years, and 0% at 36 years. Cox regression analysis indicated that impaired functional capacity, reduced mitral valve area, gradual increase in left atrial diameter and postoperative mitral insufficiency increased the reoperation rate after CMV.
When compared with percutaneous balloon or surgical open valvotomy, CMV represents a satisfactory technique in terms of simplicity, high efficacy and lower cost.
本研究旨在探讨闭式二尖瓣切开术(CMV)的长期疗效。
对1134例行CMV手术患者36年间的数据进行分析。分析通过回顾医院记录进行,随访检查主要在门诊进行。
院内死亡率(术后≤30天)为0.4%(n = 5,均为闭式手术)。心力衰竭是早期死亡的主要原因,术后周围栓塞发生5例(0.5%)。36年时无血栓栓塞发生率为99.0±0.5%。多数患者手术效果满意,仅3例出现严重二尖瓣关闭不全。CMV术后第一年88例患者(7.7%)出现二尖瓣反流。500例患者(44.1%)接受再次手术。CMV与再次手术的平均间隔时间为141.1±80.8个月(范围:1 - 436个月)。14例患者因二尖瓣反流接受再次手术,485例因二尖瓣再狭窄,5例因二尖瓣混合病变(狭窄和反流)。CMV术后10年无再次手术率为81.4±1.3%,20年为16.4±2.1%,30年为3.1±1.2%,36年为0%。Cox回归分析表明,功能能力受损、二尖瓣瓣口面积减小、左心房直径逐渐增大以及术后二尖瓣关闭不全增加了CMV术后再次手术率。
与经皮球囊或外科直视瓣膜切开术相比,CMV在操作简便性、高效性和低成本方面是一种令人满意的技术。