溶质和细胞通过紧密连接的移动。
The movement of solutes and cells across tight junctions.
作者信息
Madara J L, Parkos C, Colgan S, Nusrat A, Atisook K, Kaoutzani P
机构信息
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
出版信息
Ann N Y Acad Sci. 1992;664:47-60. doi: 10.1111/j.1749-6632.1992.tb39748.x.
Abstract
The TJ is a highly dynamic rate-limiting barrier for passive transepithelial solute flow. It is not only physiologically regulated but is modulated in various disease states as well. Such modulations occur as a result of epithelial cell interactions with immune cells or immune cell products and thus epithelial barrier function appears to be regulated in disease states.
摘要
紧密连接（TJ）是被动跨上皮溶质流动的高度动态限速屏障。它不仅受到生理调节，在各种疾病状态下也会被调节。这种调节是上皮细胞与免疫细胞或免疫细胞产物相互作用的结果，因此上皮屏障功能在疾病状态下似乎受到调节。
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