Katz Martin M, Berman Nancy
Department of Psychiatry, University of Texas Health Science Center at San Antonio and Harbor-UCLA Medical Center, Torrance, CA, USA.
Stat Med. 2003 Nov 15;22(21):3291-9. doi: 10.1002/sim.1630.
Sam Greenhouse began his involvement in mental disorders research in 1954 when appointed chief of the Theoretical Statistics and Mathematics section at the National Institute of Mental Health. He remained with the NIMH until 1966. Despite moving on to several other positions at the NIH and at the university during the ensuing years, he continued as a consultant to NIMH investigators. He also participated actively as an advisor and co-investigator on a number of important collaborative research programmes launched by the Institute in the 1970s and 1980s. His contributions to the design and methodology of the first clinical trials of drugs for the treatment of schizophrenia, to research aimed at revising the national and international classification systems for the mental disorders, and his participation in the planning of the first attempt to use the collaborative research model to test hypotheses about the genesis of a specific mental disorder (depression), are described. Finally, the signal importance of the 'profile analysis of variance' method that he and Seymour Geisser developed, to research on personality and mental disorders, is examined in detail. The authors describe applications of the method in their own research on the classification of the mental disorders, predicting response to drug treatment and the variations in the expression of mental illness across different cultures. Sam worked in mental health during an era of revolutionary changes in the diagnosis and treatment of mental disorders. The field was acutely aware of his many contributions to the progress of research and his colleagues are very grateful to have had the opportunity to work with him.
1954年，山姆·格林豪斯开始参与精神障碍研究，当时他被任命为国立精神卫生研究所理论统计与数学部门主管。他在国立精神卫生研究所工作到1966年。在随后的几年里，尽管他又在国立卫生研究院和大学担任了其他几个职位，但他继续担任国立精神卫生研究所研究人员的顾问。他还积极参与了该研究所20世纪70年代和80年代发起的一些重要合作研究项目，担任顾问和共同研究者。文中描述了他对精神分裂症治疗药物首次临床试验的设计和方法、旨在修订国家和国际精神障碍分类系统的研究，以及他参与首次尝试使用合作研究模型来检验关于特定精神障碍（抑郁症）成因假设的规划所做出的贡献。最后，详细探讨了他和西摩·盖泽尔开发的“方差轮廓分析”方法对人格和精神障碍研究的重要意义。作者描述了该方法在他们自己关于精神障碍分类、预测药物治疗反应以及不同文化中精神疾病表达差异的研究中的应用。山姆在精神障碍诊断和治疗发生革命性变革的时代从事精神卫生工作。该领域清楚地意识到他对研究进展做出的诸多贡献，他的同事们很感激有机会与他共事。
