Kaneda Mitsuhiro, Tsuda Junko, Iida Nami, Igarashi Tomomi, Tajima Hakuju, Kizu Junko, Hori Seiji
Department of Pharmacy, Sanraku Hospital, 2-5 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8326.
Jpn J Antibiot. 2003 Aug;56(4):272-80.
Since convulsions associated with the concurrent administration of enoxacin and fenbufen were reported in 1986, the concurrent administration of quinolones and anti-inflammatory drugs has been regulated to be contraindicated or carefully administered. However, the real incidence of the co-administration is not clear. We surveyed the incidence of co-administration of these drugs from the prescriptions in a community hospital. Quinolones were prescribed in 1% of the out-patients, and anti-inflammatory drugs were co-administrated in 16% of quinolone-prescribed patients. Among quinolones prescribed, levofloxacin was used most frequently. And acetaminphen (including acetaminophen-combination) was most frequently prescribed with quinolones, and anti-inflammatory drugs, which is regulated to be carefully administrated with quinolones, were frequently co-prescribed. In medical practice, quinolones were revealed to be co-administered with anti-inflammatory drugs. Since our recent report suggests that each quinolone and each anti-inflammatory drug has different activity in their drug interaction, it should be necessary to recognize the interaction of these drugs separately for their effective and safe use in clinical field.
自1986年有报告称依诺沙星与芬布芬同时使用会引发惊厥以来，喹诺酮类药物与抗炎药物的同时使用已被规定为禁忌或需谨慎使用。然而，这种联合用药的实际发生率尚不清楚。我们从一家社区医院的处方中调查了这些药物联合使用的发生率。门诊患者中1%的人开具了喹诺酮类药物，在开具喹诺酮类药物的患者中，16%的人同时使用了抗炎药物。在所开具的喹诺酮类药物中，左氧氟沙星使用最为频繁。对乙酰氨基酚（包括复方对乙酰氨基酚）与喹诺酮类药物同时开具的情况最为常见，而规定需与喹诺酮类药物谨慎联用的抗炎药物也经常被同时开具。在医疗实践中，发现喹诺酮类药物会与抗炎药物同时使用。由于我们最近的报告表明，每种喹诺酮类药物和每种抗炎药物在药物相互作用中具有不同的活性，为了在临床领域有效且安全地使用这些药物，有必要分别认识它们之间的相互作用。
