Smith J B, Tulloch J E, Meyer L J, Zone J J
Emergency Department, US Air Force Hospital Hill, Hill Air Force Base, Utah.
Arch Dermatol. 1992 Dec;128(12):1608-10.
The incidence and prevalence of dermatitis herpetiformis has never been formally evaluated in any area of the United States. Several northern European studies have shown prevalence rates ranging from 1.2 per 100,000 to 39.2 per 100,000. The present study was performed to evaluate the incidence and prevalence of dermatitis herpetiformis in Utah. Information from 240 patients diagnosed with dermatitis herpetiformis was compiled from hospital records throughout Utah, as well as the sole private dermatopathologist in the state, and from the university referral center of the state. Criteria for inclusion in the study were a clinical diagnosis of dermatitis herpetiformis plus granular deposition of IgA in dermal papillae by direct immunofluorescence of uninvolved skin, or histopathologic findings consistent with the disease. Clinical diagnosis and response to dapsone alone was considered insufficient for inclusion in the study. On the basis of these criteria, as well as exclusion of non-Utah residents, 188 of the original 240 patients qualified for the study.
The prevalence of dermatitis herpetiformis in Utah in 1987 was 11.2 per 100,000. The mean incidence for the years 1978 through 1987 was 0.98 per 100,000 per year. The mean age at onset of symptoms for male patients was 40.1 years, and that for female patients was 36.2 years. The male-female ratio was 1.44:1.
This represents the first evaluation of the incidence and prevalence of dermatitis herpetiformis in the United States. These results are similar to those of the previous studies, probably because of Utah's largely northern European ancestry. This population base, plus a much smaller than average black and Oriental population, is likely to have produced a higher incidence and prevalence in Utah than would be seen in other areas of the United States.
在美国任何地区，疱疹样皮炎的发病率和患病率从未得到过正式评估。北欧的几项研究显示患病率在每10万人1.2例至每10万人39.2例之间。本研究旨在评估犹他州疱疹样皮炎的发病率和患病率。从犹他州各地医院记录以及该州唯一的私立皮肤病理学家和该州大学转诊中心收集了240例被诊断为疱疹样皮炎患者的信息。纳入研究的标准是疱疹样皮炎的临床诊断加上通过未受累皮肤的直接免疫荧光显示真皮乳头中有IgA颗粒沉积，或组织病理学结果与该病一致。仅临床诊断和对氨苯砜的反应被认为不足以纳入研究。基于这些标准，以及排除非犹他州居民，最初的240例患者中有188例符合研究条件。
1987年犹他州疱疹样皮炎的患病率为每10万人11.2例。1978年至1987年的平均发病率为每年每10万人0.98例。男性患者出现症状的平均年龄为40.1岁，女性患者为36.2岁。男女比例为1.44:1。
这是美国首次对疱疹样皮炎的发病率和患病率进行评估。这些结果与之前的研究相似，可能是因为犹他州的居民大多有北欧血统。这种人口基础，加上远低于平均水平的黑人和东方人口，可能使得犹他州的发病率和患病率高于美国其他地区。
