Söllner Thomas H, Sequeira Sonia
Memorial Sloan-Kettering Cancer Center, Cellular Biochemistry & Biophysics Program, New York, NY 10021, USA.
Cell. 2003 Oct 17;115(2):127-9. doi: 10.1016/s0092-8674(03)00811-0.
Nitric oxide is a diffusible molecule with profound effects on regulated exocytosis in several biological systems-however, the molecular targets remain elusive. In this issue of Cell, Matsushita et al. report that in aortic endothelial cells, S-nitrosylation of NSF, an ATPase essential for the activation of the membranefusion machinery, inhibits the exocytosis of Weibel-Palade bodies, secretory granules containing a cocktail of mediators essential to the regulation of vascular vessel tone.
一氧化氮是一种可扩散的分子，在多个生物系统中对调节性胞吐作用具有深远影响——然而，其分子靶点仍不明确。在本期《细胞》杂志中，松下等人报道，在主动脉内皮细胞中，NSF（一种对膜融合机制激活至关重要的ATP酶）的S-亚硝基化作用会抑制魏尔-帕拉德小体的胞吐作用，魏尔-帕拉德小体是一种分泌颗粒，含有对血管张力调节至关重要的多种介质。
