[Isolation and evaluation of the structure of the new anthracycline antibiotics rubomycins F and H].
作者信息
Fomicheva E V, Fedorova G B, Potapova N P, Katrukha G S
出版信息
Antibiot Khimioter. 1992 Aug;37(8):27-9.
PMID:1456819
Abstract
The rubomycin complex produced by Streptomyces coeruleorubidus 4-157 was studied and the two novel anthracyclines i.e. rubomycins F and H were isolated. The study of the physicochemical properties of the novel antibiotics in comparison with rubomycin C (daunomycin) and the specially prepared 3'-N-carbmethoxyrubomycin C showed that rubomycin F was 3'-N-carbethoxydaunomycin and rubomycin H was 3'-N-carbmethoxydaunomycin. Therefore, rubomycins F and H are novel representatives of natural anthracyclines undescribed previously.
摘要
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