Fedorova G B, Golova T P, Arkhangel'skaia N M, Lazhko E I, Abramova E A, Bychkova O P, Polunin A D, Katrukha G S
Antibiot Khimioter. 1996 Mar;41(3):3-8.
In the programme of screening of biologically active secondary metabolites produced by Streptomyces coeruleorubidus 2679 a new reddish-violet component (rubomycin Q1) with antibacterial and cytotoxic activity was isolated from the culture fluid of the organism. Some physico-chemical and biological properties of a chromatographically pure rubomycin Q1 were investigated. It was shown with the use of 1H NMR, UV, IR and mass spectrometry that rubomycin Q1 was an anthracycline antibiotic (9,10-anhydro-13-desoxycarminomycin).
在对天蓝色链霉菌2679产生的生物活性次级代谢产物进行筛选的过程中,从该微生物的培养液中分离出一种具有抗菌和细胞毒性活性的新红紫色成分(鲁博霉素Q1)。对色谱纯的鲁博霉素Q1的一些物理化学和生物学性质进行了研究。通过1H NMR、UV、IR和质谱分析表明,鲁博霉素Q1是一种蒽环类抗生素(9,10-脱水-13-脱氧卡红菌素)。