Chia S E, Ong C N, Lee S T, Tsakok F H
Department of Community, Occupational and Family Medicine, National University of Singapore, National University Hospital.
Arch Androl. 1992 Sep-Oct;29(2):177-83. doi: 10.3109/01485019208987722.
The study consisted of 35 male subjects attending an andrology clinic. The subjects all had poor sperm parameters that could not be attributed to any known medical cause. The objective was to evaluate the relation between various seminal characteristics (volume, total sperm count, sperm viability, proportion of progressively motile sperm, and different sperm morphology) and the blood concentrations of lead, cadmium, mercury, copper, and zinc. The mean blood concentrations of lead, mercury, copper, and zinc were within the normal values; cadmium concentration (1.35 micrograms/L) was much higher than the norms. Asthenozoospermic subjects had significantly (p less than .025) higher blood cadmium levels than normozoospermic subjects. No significant differences were noted between the two groups for mean concentration of mercury, zinc, and copper in blood. Significant correlations were observed between blood cadmium levels and volume of semen, midpiece defects, and immature forms of spermatozoa. High blood cadmium levels may have an effect on spermatogenesis. Possible reasons for the high blood cadmium levels among the subjects are discussed.
该研究包括35名前往男科诊所就诊的男性受试者。这些受试者的精子参数均较差，且无法归因于任何已知的医学原因。目的是评估各种精液特征（体积、精子总数、精子活力、进行性运动精子比例以及不同的精子形态）与血液中铅、镉、汞、铜和锌浓度之间的关系。铅、汞、铜和锌的平均血液浓度在正常范围内；镉浓度（1.35微克/升）远高于正常标准。弱精子症患者的血液镉水平显著高于正常精子症患者（p小于0.025）。两组之间血液中汞、锌和铜的平均浓度没有显著差异。血液镉水平与精液体积、中段缺陷和未成熟精子形式之间存在显著相关性。高血液镉水平可能对精子发生有影响。文中讨论了受试者血液镉水平高的可能原因。
