血液和精浆中钙、镁、锌及铜对男性精液参数的影响。

The impact of calcium, magnesium, zinc, and copper in blood and seminal plasma on semen parameters in men.

作者信息

Wong W Y, Flik G, Groenen P M, Swinkels D W, Thomas C M, Copius-Peereboom J H, Merkus H M, Steegers-Theunissen R P

机构信息

Department of Obstetrics and Gynecology, University Medical Centre Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

出版信息

Reprod Toxicol. 2001 Mar-Apr;15(2):131-6. doi: 10.1016/s0890-6238(01)00113-7.

DOI:10.1016/s0890-6238(01)00113-7

PMID:11297872

Abstract

To investigate the impact of calcium, magnesium, zinc, and copper in blood and seminal plasma on semen parameters, 107 fertile and 103 subfertile males provided a standardized blood and semen specimen. Total calcium and magnesium concentrations were determined with colorimetric end point assay procedures. Zinc and copper were determined by flame atomic absorption spectrophotometer (AAS). Semen analysis was performed according to World Health Organization guidelines (1992). The concentrations of calcium, magnesium, zinc, and copper in blood and seminal plasma were not different between the subfertile and fertile group. Weak correlations were demonstrated between blood plasma zinc concentrations and sperm count (rs = 0.18), sperm motility (rs = 0.15), and abnormal sperm morphology (rs = 0.13). Zinc and magnesium concentrations in seminal plasma correlated weakly with sperm count (rs = 0.17 and rs = 0.16, respectively), and copper concentrations in blood plasma with motility (rs = 0.25). Strong correlations were found between calcium, magnesium, and zinc in seminal plasma. Although calcium, magnesium, zinc, and copper play an essential role in spermatogenesis and fertility, the determination of these elements in blood and seminal plasma does not discriminate on the basis of fertility in this group of men.

摘要

为研究血液和精浆中钙、镁、锌和铜对精液参数的影响，107名生育能力正常的男性和103名生育能力低下的男性提供了标准化的血液和精液样本。采用比色终点分析法测定总钙和镁浓度。锌和铜通过火焰原子吸收分光光度计（AAS）测定。精液分析按照世界卫生组织指南（1992年）进行。生育能力低下组和生育能力正常组血液和精浆中钙、镁、锌和铜的浓度没有差异。血浆锌浓度与精子计数（rs = 0.18）、精子活力（rs = 0.15）和异常精子形态（rs = 0.13）之间存在弱相关性。精浆中锌和镁浓度与精子计数之间存在弱相关性（分别为rs = 0.17和rs = 0.16），血浆中铜浓度与精子活力之间存在弱相关性（rs = 0.25）。精浆中的钙、镁和锌之间存在强相关性。尽管钙、镁、锌和铜在精子发生和生育能力中起着重要作用，但在这组男性中，测定血液和精浆中的这些元素并不能根据生育能力进行区分。