Dhamala Mukeshwar, Pagnoni Giuseppe, Wiesenfeld Kurt, Zink Caroline F, Martin Megan, Berns Gregory S
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA.
Neuroimage. 2003 Oct;20(2):918-26. doi: 10.1016/S1053-8119(03)00304-5.
Using functional magnetic resonance imaging (fMRI), we studied the neural correlates of the complexity of rhythmic finger tapping. Our experiments measured the brain activity of 13 subjects performing rhythmic tapping on a response box with multistable rhythms of 1 to 5 different interresponse intervals. From the button press response times, we constructed phase portraits where we identified the number of clusters of periodic points in a rhythm that corresponded to the number of different beats of the rhythm performed. We then constructed a statistical model for correlation analysis involving the following behavioral parameters: rate of tapping and number of beats in a rhythm. The tapping rate correlated with the brain activity in the ipsilateral pre/postcentral gyrus, and the number of beats (complexity) was correlated with activations in the primary motor cortex, supplementary motor area, basal ganglia, thalamus, and cerebellum. A region of interest (ROI) average analysis showed that the complexity of a rhythm had a differential correlation with the activity in these regions. The cerebellum and the thalamus showed increasing activity, and the basal ganglia showed decreasing activity with complexity of a rhythm. These results identify the areas involved in a rhythm generation and the modulation of brain activity with the complexity.
我们使用功能磁共振成像（fMRI）研究了有节奏的手指敲击复杂性的神经关联。我们的实验测量了13名受试者在反应盒上进行有节奏敲击时的大脑活动，这些节奏具有1至5种不同反应间隔的多稳态节奏。根据按键反应时间，我们构建了相图，在相图中我们确定了节奏中周期点簇的数量，该数量对应于所执行节奏的不同节拍数。然后，我们构建了一个用于相关分析的统计模型，该模型涉及以下行为参数：敲击速率和节奏中的节拍数。敲击速率与同侧中央前/后回的大脑活动相关，节拍数（复杂性）与初级运动皮层、辅助运动区、基底神经节、丘脑和小脑的激活相关。感兴趣区域（ROI）平均分析表明，节奏的复杂性与这些区域的活动具有不同的相关性。随着节奏复杂性的增加，小脑和丘脑的活动增加，而基底神经节的活动减少。这些结果确定了参与节奏生成以及大脑活动随复杂性调节的区域。
