Maestú Fernando, Simos Panagiotis G, Campo Pablo, Fernández Alberto, Amo Carlos, Paul Nuria, González-Marqués Javier, Ortiz Tomás
Centro de Magnetoencefalografia Dr Pérez Modrego, Universidad Complutense Madrid, Madrid, Spain.
Neuroimage. 2003 Oct;20(2):1110-21. doi: 10.1016/S1053-8119(03)00309-4.
In this study we examined spatiotemporal profiles of brain activity in the context of tasks designed to engage different verbal learning strategies (serial order, phonological, and semantic). The profile of activation associated with the serial-order strategy, which resulted in poor recall performance, featured early activation of the inferior frontal, sensorimotor, and insular region in the left hemisphere, between 200 and 400 ms after stimulus onset. Subsequently, activation was more prominent in dorsolateral prefrontal cortices bilaterally. In contrast, activation profiles associated with the phonological strategy featured predominantly activation of the superior temporal gyrus in the left hemisphere between 500 and 600 ms. Predominant activation of the left middle temporal gyrus, between 500 and 700 ms, was the key feature of the activation profile observed when the semantic elaboration strategy was utilized. These results suggest that different brain circuits are engaged to support learning of new verbal information as a function of the level and type of initial processing applied to the stimuli.
在本研究中，我们在旨在运用不同言语学习策略（序列顺序、语音和语义）的任务背景下，研究了大脑活动的时空特征。与序列顺序策略相关的激活特征，该策略导致较差的回忆表现，其特征是在刺激开始后200至400毫秒之间，左半球的额下回、感觉运动区和岛叶区域早期激活。随后，双侧背外侧前额叶皮层的激活更为显著。相比之下，与语音策略相关的激活特征主要是在500至600毫秒之间左半球颞上回的激活。当运用语义加工策略时，观察到的激活特征的关键特征是在500至700毫秒之间左颞中回的主要激活。这些结果表明，根据应用于刺激的初始加工的水平和类型，不同的脑回路参与支持新言语信息的学习。
