Monaco Roberto, Boscaino Amedeo, Di Blasi Arturo, D'Antonio Antonio, Profeta Giovanni, De Falco Raffaele, Nappi Oscar
Operative Unit of Anatomic Pathology, A. Cardarelli Hospital, Naples, Italy.
Neuropathology. 2003 Sep;23(3):219-24. doi: 10.1046/j.1440-1789.2003.00497.x.
Endodermal cysts of the central neuraxis are benign, non-neoplastic epithelium-lined cysts arising from endodermal tissue that have been displaced early in fetal life. Intracranial endodermal cysts are rare and usually located in the posterior fossa. The present study involves a 36-year-old man with a typical epithelial cyst in the posterior fossa. Microscopically, the cyst has a simple columnar epithelium with mucus-producing cells, containing an area composed of dysplastic epithelium with evidence of an intraepithelial carcinoma. The atypical cells have a high proliferative fraction demonstrated by Ki-67 immunostain. Based on these findings, the authors view this case as evidence of a malignant transformation of a classic endodermal cyst. The clinicopathologic features and a review of the literature are discussed.
中枢神经轴内胚层囊肿是良性的、非肿瘤性的内衬上皮囊肿，起源于胎儿早期移位的内胚层组织。颅内内胚层囊肿罕见，通常位于后颅窝。本研究涉及一名36岁男性，其在后颅窝有一个典型的上皮囊肿。显微镜下，囊肿具有含黏液分泌细胞的单层柱状上皮，包含一个由发育异常上皮组成的区域，并有上皮内癌的证据。非典型细胞具有高增殖分数，这通过Ki-67免疫染色得以证实。基于这些发现，作者将此病例视为经典内胚层囊肿发生恶性转化的证据。文中讨论了其临床病理特征并对文献进行了综述。
