Cherian P Joseph, Radhakrishnan V V, Radhakrishnan K
R. Madhavan Nayar Center for Comprehensive Epilepsy Care and Department of Pathology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 695-011, India.
Neurol India. 2003 Jun;51(2):277-9.
Temporal lobe epilepsy (TLE) associated with mesial temporal sclerosis (MTS), mesial TLE (MTLE), is the commonest medically refractory adult epilepsy syndrome. Corpora amylacea (CoA) have been shown to be a marker of MTS. We compared 9 patients with MTS who had dense deposition of CoA in their hippocampi with 25 patients with MTS who did not have CoA. The patients with CoA were significantly older and they showed a trend towards having a significantly longer duration of epilepsy. The postoperative seizure outcome at 2 years was not different in the 2 groups. Our results could indicate the progressive nature of the pathology of MTS, probably indicating excitotoxic damage due to recurrent seizures, but they need to be verified by clinicopathological correlation among a larger number of patients with MTLE.
与内侧颞叶硬化（MTS）相关的颞叶癫痫（TLE），即内侧颞叶癫痫（MTLE），是最常见的药物难治性成人癫痫综合征。淀粉样体（CoA）已被证明是MTS的一个标志物。我们将9例海马体中CoA密集沉积的MTS患者与25例没有CoA的MTS患者进行了比较。有CoA的患者年龄明显更大，且有癫痫发作持续时间明显更长的趋势。两组患者术后2年的癫痫发作结果并无差异。我们的结果可能表明MTS病理的进展性，可能提示由于反复癫痫发作导致的兴奋性毒性损伤，但需要通过对大量MTLE患者进行临床病理相关性分析来加以验证。
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