School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia.
Department of Respiratory Medicine and Sleep, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland.
Sci Rep. 2021 Oct 22;11(1):20892. doi: 10.1038/s41598-021-99795-8.
Corpora amylacea (CoA) are spherical aggregates of glucose polymers and proteins within the periventricular, perivascular and subpial regions of the cerebral cortex and the hippocampal cornu ammonis (CA) subfields. The present study quantified the distribution of CoA in autopsied hippocampi of patients with obstructive sleep apnoea (OSA) using ethanolamine-induced fluorescence. CoA were observed in 29 of 30 patients (96.7%). They were most abundant in periventricular regions (wall of lateral ventricle, alveus, fimbria and CA4), rarely found in the CA3 and CA1, and undetectable in the CA2 or subiculum. A spatiotemporal sequence of CoA deposition was postulated, beginning in the fimbria and progressively spreading around the subpial layer until they extended medially to the wall of the lateral ventricle and laterally to the collateral sulcus. This ranked CoA sequence was positively correlated with CoA packing density (count and area fraction) and negatively correlated with CoA minimum diameters (p < 0.05). Although this sequence was not correlated with age or body mass index (BMI), age was positively correlated with the mean and maximum diameters of CoA. These findings support the view that the spatiotemporal sequence of CoA deposition is independent of age, and that CoA become larger due to the accretion of new material over time.
脑淀粉样血管病（CoA）是位于大脑皮质室周、血管周围和软脑膜下区以及海马角（CA）亚区的葡萄糖聚合物和蛋白质的球形聚集物。本研究使用乙醇胺诱导荧光定量分析了阻塞性睡眠呼吸暂停（OSA）患者尸检海马 CoA 的分布。在 30 名患者中的 29 名（96.7%）观察到 CoA。它们在室周区域（侧脑室壁、穹窿、终纹和 CA4）最为丰富，在 CA3 和 CA1 中很少发现，在 CA2 或下托中无法检测到。提出了 CoA 沉积的时空顺序，从终纹开始，逐渐向软脑膜下层扩散，直到它们向侧脑室壁内侧延伸，向侧副沟外侧延伸。这种 CoA 序列与 CoA 堆积密度（计数和面积分数）呈正相关，与 CoA 最小直径呈负相关（p<0.05）。尽管该序列与年龄或体重指数（BMI）无关，但年龄与 CoA 的平均直径和最大直径呈正相关。这些发现支持 CoA 沉积的时空顺序与年龄无关，并且由于随着时间的推移新物质的积累，CoA 会变得更大。
