创伤后立即使用普萘洛尔治疗可降低创伤后两个月的创伤后应激障碍发生率。
Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma.
作者信息
Vaiva Guillaume, Ducrocq François, Jezequel Karine, Averland Benoit, Lestavel Philippe, Brunet Alain, Marmar Charles R
机构信息
Clinical School of Psychiatry, University of Lille II, Lille, France.
出版信息
Biol Psychiatry. 2003 Nov 1;54(9):947-9. doi: 10.1016/s0006-3223(03)00412-8.
BACKGROUND
This study investigated the efficacy of propranolol prescribed shortly after trauma exposure in the prevention of posttraumatic stress disorder (PTSD) symptoms and diagnosis.
METHODS
Eleven patients received 40 mg of propranolol 3 times daily for 7 days, followed by a taper period of 8-12 days. They were compared with eight patients who refused propranolol but agreed to participate in the study. Though nonrandomized, the two groups did not differ on demographics, exposure characteristics, physical injury severity, or peritraumatic emotional responses.
RESULTS
Posttraumatic stress disorder rates were higher in the group who refused propranolol (3/8) compared with those who received the medication (1/11), as were the levels of PTSD symptoms (U = 85, p =.037).
CONCLUSIONS
Our results are consistent with earlier findings and suggest that propranolol may be useful for mitigating PTSD symptoms or perhaps even preventing the development of PTSD.
背景
本研究调查了创伤暴露后不久开具的普萘洛尔在预防创伤后应激障碍（PTSD）症状和诊断方面的疗效。
方法
11名患者每天3次服用40毫克普萘洛尔，共7天，随后为8至12天的减量期。将他们与8名拒绝服用普萘洛尔但同意参与研究的患者进行比较。尽管未进行随机分组，但两组在人口统计学、暴露特征、身体损伤严重程度或创伤期间的情绪反应方面没有差异。
结果
拒绝服用普萘洛尔的组（3/8）的创伤后应激障碍发生率高于服用药物的组（1/11），PTSD症状水平也是如此（U = 85，p =.037）。
结论
我们的结果与早期研究结果一致，表明普萘洛尔可能有助于减轻PTSD症状，甚至可能预防PTSD的发生。
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