曼氏血吸虫感染患者CD4(+) T细胞和单核细胞表面人类免疫缺陷病毒1型共受体CCR5和CXCR4密度增加。
Increased density of human immunodeficiency virus type 1 coreceptors CCR5 and CXCR4 on the surfaces of CD4(+) T cells and monocytes of patients with Schistosoma mansoni infection.
作者信息
Secor W Evan, Shah Amil, Mwinzi Pauline M N, Ndenga Bryson A, Watta Caroline O, Karanja Diana M S
机构信息
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30341, USA.
出版信息
Infect Immun. 2003 Nov;71(11):6668-71. doi: 10.1128/IAI.71.11.6668-6671.2003.
Distribution of chemokine receptors CCR5 and CXCR4, which are also coreceptors for human immunodeficiency virus type 1 invasion of cells, was measured on the surfaces of CD4(+) T cells and monocytes in peripheral blood samples from a group of Kenyan car washers. Patients with active schistosomiasis displayed higher cell surface densities of these receptors than did cured schistosomiasis patients.
趋化因子受体CCR5和CXCR4也是1型人类免疫缺陷病毒入侵细胞的共受体，对一组肯尼亚洗车工外周血样本中的CD4(+) T细胞和单核细胞表面的这些受体分布进行了检测。活动性血吸虫病患者这些受体的细胞表面密度高于已治愈的血吸虫病患者。
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