肠炎沙门氏菌鼠伤寒血清型对orgC基因产物的分泌
Secretion of the orgC gene product by Salmonella enterica serovar Typhimurium.
作者信息
Day James B, Lee Catherine A
机构信息
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
Infect Immun. 2003 Nov;71(11):6680-5. doi: 10.1128/IAI.71.11.6680-6685.2003.
Abstract
HilA activates the transcription of genes on Salmonella pathogenicity island 1 (SPI1), which encodes a type III secretion system (TTSS). Previous studies showed that transposon insertions in orgC, a gene located on SPI1, increase hilA expression. We characterize the orgC gene product and show that it is secreted via the SPI1 TTSS. We propose a model whereby OrgC functions as a secreted repressor of the SPI1 virulence genes.
摘要
HilA激活沙门氏菌致病岛1（SPI1）上基因的转录，该致病岛编码III型分泌系统（TTSS）。先前的研究表明，位于SPI1上的orgC基因发生转座子插入会增加hilA的表达。我们对orgC基因产物进行了表征，并表明它是通过SPI1 TTSS分泌的。我们提出了一个模型，即OrgC作为SPI1毒力基因的分泌型阻遏物发挥作用。
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