两性霉素甲酯与两性霉素B极性头部在有水存在时构象的比较理论研究
Comparative theoretical study of the conformations of amphotericin methyl ester and amphotericin B polar heads in the presence of water.
作者信息
Meddeb S, Bergès J, Caillet J, Langlet J
机构信息
CNRS, Université Pierre et Marie Curie, Paris, France.
出版信息
Biochim Biophys Acta. 1992 Dec 9;1112(2):266-72. doi: 10.1016/0005-2736(92)90401-7.
PMID:1457458
Abstract
Amphotericin methyl ester (AmE) is an interesting derivative of amphotericin B (AmB) because of its enhancement of selectivity against the fungicells. Both AmB and AmE molecules differ by the structure of their polar heads. This work deals with a theoretical study of conformations of the polar head of AmE in the presence of hydration water molecules. The results will be compared with our previous work concerning AmB.
摘要
两性霉素甲酯（AmE）是两性霉素B（AmB）的一种有趣衍生物，因为它提高了对真菌细胞的选择性。AmB和AmE分子的极性头部结构不同。这项工作涉及在存在水化水分子的情况下对AmE极性头部构象的理论研究。结果将与我们之前关于AmB的工作进行比较。
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