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[儿童脑肿瘤]

[Brain tumors in children].

作者信息

Perek Danuta, Perek-Polnik Marta

机构信息

Klinika Onkologii Instytutu Pomnik-Centrum Zdrowia Dziecka, 04-730 Warszawa, Al. Dzieci Polskich 20.

出版信息

Przegl Lek. 2003;60 Suppl 5:27-34.

Abstract

Primary central nervous system (CNS) neoplasms are the most common solid tumors in children. During the last two decades progress in diagnostic procedures and treatment has been made. New techniques of imaging (CT, MRI), neurosurgery, intensive care and the introduction of intensive chemotherapy and refined radiotherapy had the greatest impact on this progress. Nevertheless, out of all pediatric malignancies this group of patients has the worst prognosis. To improve survival optimal treatment modalities are searched for. This paper presents brain tumors epidemiology, etiology aspects, classification, clinical symptoms, diagnostic procedures and current treatment strategies in CNS tumors in children such as: medulloblastoma/PNET, high and low grade gliomas, ependymomas, germ cell tumors and brain stem tumors. Age of the patients is considered in all tumors as there is a specific philosophy of treatment in small children. We are also presenting directions of recent clinical trials and the aims of pediatric oncologists in improving the effectiveness of treatment and quality of life of a cured child.

摘要

原发性中枢神经系统(CNS)肿瘤是儿童最常见的实体瘤。在过去二十年中,诊断程序和治疗方面取得了进展。新的成像技术(CT、MRI)、神经外科手术、重症监护以及强化化疗和精确放疗的引入对这一进展产生了最大影响。然而,在所有儿科恶性肿瘤中,这组患者的预后最差。为了提高生存率,人们正在寻找最佳的治疗方式。本文介绍了儿童中枢神经系统肿瘤的流行病学、病因学、分类、临床症状、诊断程序和当前治疗策略,如:髓母细胞瘤/原始神经外胚层肿瘤、高低级别胶质瘤、室管膜瘤、生殖细胞瘤和脑干肿瘤。所有肿瘤都考虑了患者的年龄,因为小儿有特定的治疗理念。我们还介绍了近期临床试验的方向以及儿科肿瘤学家在提高治疗效果和治愈儿童生活质量方面的目标。

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