Wallukat Gerd, Podlowski Svenia, Nissen Eberhard, Morwinski Rosemarie, Csonka Csaba, Tosaki Arpad, Blasig Ingolf E
Max Delbrück Centrum für Molekulare Medizin, Berlin, Germany.
Mol Cell Biochem. 2003 Sep;251(1-2):67-75.
Eighteen month old spontaneously hypertensive rats (SHR-rats) showed myocardial dysfunction and autoantibodies directed against the beta1-adrenoceptor similarly as known in human dilated cardiomyopathy or Chagas' disease. The agonist-like antibodies were able to activate the beta1-adrenoceptor mediated signal transduction cascade in cultured rat cardiomyocytes and induced a long-lasting stimulatory effect resulting in a harmful adrenergic overdrive. The antibodies recognized an epitope of the second extracellular loop of the beta1-adrenoceptor identical to that epitope identified in Chagas' disease. In conclusion, our assumption is supported that old SHR-rat are an useful animal model for investigating the role of anti-beta1-adrenoceptor antibodies in the induction of human cardiomyopathy.
18个月大的自发性高血压大鼠（SHR大鼠）表现出心肌功能障碍，并且存在针对β1 - 肾上腺素能受体的自身抗体，这与人类扩张型心肌病或恰加斯病中已知的情况类似。这些激动剂样抗体能够激活培养的大鼠心肌细胞中β1 - 肾上腺素能受体介导的信号转导级联反应，并诱导持久的刺激作用，导致有害的肾上腺素能过度驱动。这些抗体识别出β1 - 肾上腺素能受体第二个细胞外环的一个表位，该表位与在恰加斯病中鉴定出的表位相同。总之，我们的假设得到了支持，即老年SHR大鼠是研究抗β1 - 肾上腺素能受体抗体在人类心肌病诱导中作用的有用动物模型。
