来自蛇足石杉的锯齿烯型三萜类化合物。

Serratene-type triterpenoids from Huperzia serrata.

作者信息

Zhou Hui, Tan Chang-Heng, Jiang Shan-Hao, Zhu Da-Yuan

机构信息

State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.

出版信息

J Nat Prod. 2003 Oct;66(10):1328-32. doi: 10.1021/np0301590.

DOI:10.1021/np0301590

PMID:14575432

Abstract

Seven new and 15 known serratene-type triterpenoids were isolated from the whole plant of Huperzia serrata. The structures of these new triterpenoids were elucidated as 21alpha-hydroxyserrat-14-en-3beta-yl p-dihydrocoumarate (1), 21alpha-hydroxyserrat-14-en-3beta-yl dihydrocaffeate (2), 21alpha-hydroxyserrat-14-en-3beta-yl propanedioic acid monoester (3), 3alpha,21alpha-dihydroxyserrat-14-en-24-oic acid (4), 16-oxo-3alpha,21beta-dihydroxyserrat-14-en-24-al (5), 16-oxo-3alpha,21beta-dihydroxyserrat-14-en-24-oic acid (6), and 16-oxo-21beta-hydroxyserrat-14-en-3alpha-yl acetate (7), respectively, by means of spectroscopic analysis.

摘要

从蛇足石杉全草中分离得到7个新的和15个已知的锯齿烯型三萜类化合物。通过光谱分析，这些新三萜类化合物的结构分别被鉴定为21α-羟基锯齿-14-烯-3β-基对二氢香豆酸酯（1）、21α-羟基锯齿-14-烯-3β-基二氢咖啡酸酯（2）、21α-羟基锯齿-14-烯-3β-基丙二酸单酯（3）、3α,21α-二羟基锯齿-14-烯-24-酸（4）、16-氧代-3α,21β-二羟基锯齿-14-烯-24-醛（5）、16-氧代-3α,21β-二羟基锯齿-14-烯-24-酸（6）和16-氧代-21β-羟基锯齿-14-烯-3α-基乙酸酯（7）。