Lv Wen, Zhang Guang-Mei, Sui Li-Hua, Wang Jing
Department of Gynecology, the Third Affiliated Hospital Harbin Medical University, Harbin 150040, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2003 Oct;24(10):924-7.
To define a correlation between different human papillomavirus (HPV) types and telomerase activity in cervical cancer.
Telomerase activity was detected by TRAP-PCR, and different HPV type was determined by PCR in 83 cervical cancer, 47 cervical intraepithelial neoplasia (CIN) and 10 normal cervix cases.
With regard to positive rates of telomerase and HPV 16/18: the results were cervical cancer > CIN > normal cervix, CIN III > CIN I, II; with regard to HPV 6/11 positive rate: the results showed CIN I, II > CIN III. Positive rates of telomerase cervical cancer and HPV were bearing on grading and staging, but they did not correlate with histologic subtypes. Positive rate of HPV 6/11 had nothing to do with grading, staging and histologic patterns. On expression strength of telomerase and HPV 16/18: the results showed cervical cancer > CIN, CIN III > CIN I, II. Regard to HPV 6/11'expression strength: the results showed CIN I, II > CIN III, CIN > cervical carcinoma.
HPV 16/18 infection seemed to have played an important role in carcinogenesis of cervical lesions by activation of telomerase.
