Liguori Maria, Sawcer Stephen, Setakis Efrosini, Compston Alastair, Giordano Mara, D'Alfonso Sandra, Mellai Marta, Malferrari Giulia, Trojano Maria, Livrea Paolo, De Robertis Francesca, Massacesi Luca, Repice Anna, Ballerini Clara, Biagioli Tiziana, Bomprezzi Roberto, Cannoni Stefania, Ristori Giovanni, Salvetti Marco, Grimaldi Luigi M E, Biunno Ida, Comi Giancarlo, Leone Maurizio, Ferro Isabella, Naldi Paola, Milanese Clara, Gellera Cinzia, Loredana La Mantia, Savettieri Giovanni, Salemi Giuseppe, Aridon Paolo, Caputo Domenico, Rosa Guerini Franca, Ferrante Pasquale, Momigliano-Richiardi Patricia
Dipartimento di Scienze Neurologiche e Psichiatriche, Univ. Bari, Italy.
J Neuroimmunol. 2003 Oct;143(1-2):97-100. doi: 10.1016/j.jneuroim.2003.08.020.
We have systematically screened the genome for evidence of linkage disequilibrium (LD) with multiple sclerosis (MS) by typing 6000 microsatellite markers in case-control and family based (AFBAC) cohorts from the Italian population. DNA pooling was used to reduce the genotyping effort involved. Four DNA pools were considered: cases (224 Italian MS patients), controls (231 healthy Italians), index (185 index cases from trio families) and parents (the 370 parents of the patient included in the Index pool), respectively. After refining analysis of the most promising 14 markers to emerge from this screening process, only marker D2S367 retained evidence for association.
