Synthesis, cytotoxicity and antiviral activity of podophyllotoxin analogues modified in the E-ring.
作者信息
Castro M Angeles, Miguel del Corral José M, Gordaliza Marina, Gómez-Zurita M Antonia, de la Puente M Luz, Betancur-Galvis Liliana A, Sierra Jelver, San Feliciano Arturo
机构信息
Departamento de Química Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, 37007 Salamanca, Spain.
出版信息
Eur J Med Chem. 2003 Oct;38(10):899-911. doi: 10.1016/j.ejmech.2003.05.001.
Several podophyllotoxin derivatives modified in the E-ring were prepared and evaluated for their cytotoxicity on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28) and for their antiherpetic activity against Herpes simplex virus type II. The trimethoxyphenyl moiety was oxidized to ortho-quinone and further condensed with diamines and enamines to form different heterocycles. Most of the compounds maintained their cytotoxicity at the muM level and some of them showed antiherpetic activity.
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