Derk C T, Vivino F B, Kenyon L, Mandel S
Thomas Jefferson University Hospital, Pennsylvania, Philadelphia, USA.
Clin Rheumatol. 2003 Oct;22(4-5):324-8. doi: 10.1007/s10067-003-0715-4.
We report a patient with systemic lupus erythematosus (SLE) and secondary Sjögren's syndrome (SS) who developed inclusion body myositis (IBM) which, contrary to the typical presentation of this disorder, was symmetrical in nature although the diagnosis was only made after electron microscopy was performed. Therapy with increased doses of methotrexate proved to be beneficial, with the patient having full recovery after 8 months of therapy. It appears that a subset of IBM may be related to autoimmune disorders, an issue that was disputed in the past, and these patients may have a better prognosis than typical IBM patients. This is the first case report of IBM in a patient who had the dual diagnosis of SLE and SS.
我们报告了一名患有系统性红斑狼疮（SLE）和继发性干燥综合征（SS）的患者，该患者发展为包涵体肌炎（IBM）。与这种疾病的典型表现相反，其症状本质上是对称的，不过是在进行电子显微镜检查后才得以确诊。事实证明，增加甲氨蝶呤剂量进行治疗是有益的，该患者在治疗8个月后完全康复。看来，一部分IBM病例可能与自身免疫性疾病有关，这一问题在过去曾存在争议，而且这些患者的预后可能比典型的IBM患者更好。这是首例关于同时患有SLE和SS的患者发生IBM的病例报告。
