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[子宫颈诊断性锥切术及其对韦特海姆-梅格斯子宫切除术后患者生存率的影响]

[Diagnostic conization of the uterine cervix and its effect on survival of patients after Wertheim-Meigs hysterectomy].

作者信息

Ivanov S

出版信息

Akush Ginekol (Sofiia). 2003;42(4):3-6.

Abstract

The aim of this retrospective work was to evaluate the diagnostic conization and its influence on morbidity and survival of patients with cervical cancer IB and IIA stage after radical hysterectomy a modo Wertheim-Meigs. The impact and influence of the irradical conization on the lymph node metastases and prognosis was analyzed. 535 patients in stage IB and IIA were examined for the period of 1990 and 2002. All of them were radically operated by Wertheim-Meigs method. There were 35 patients mainly from the countryside, who were treated by conization priory to radical hysterectomy. The time interval between the conization and the radical hysterectomies was between 5 and 8 weeks. The surgical morbidity and death incidence for patients with prior conization was not significantly different from other patients with directly radical hysterectomies. The survival was not significantly different between the two groups (84% vs 81%, p = 0.21). The Multivariate analysis which we used showed us that the irradical conization is not connected with higher risk of metastases or poor prognosis. We think that in early cervical cancer, the diagnostic conization has no adverse negative effect on the following radical hysterectomy a modo Werheim-Meigs. The irradical conization has no influence on prognosis.

摘要

这项回顾性研究的目的是评估诊断性锥切术及其对采用韦特海姆-梅格斯式根治性子宫切除术后的宫颈癌IB期和IIA期患者发病率和生存率的影响。分析了非根治性锥切术对淋巴结转移和预后的影响。在1990年至2002年期间对535例IB期和IIA期患者进行了检查。所有患者均采用韦特海姆-梅格斯方法进行根治性手术。其中有35例主要来自农村的患者,在根治性子宫切除术之前接受了锥切术治疗。锥切术与根治性子宫切除术之间的时间间隔为5至8周。先行锥切术患者的手术发病率和死亡率与直接接受根治性子宫切除术的其他患者相比无显著差异。两组患者的生存率无显著差异(84%对81%,p = 0.21)。我们采用的多变量分析表明,非根治性锥切术与更高的转移风险或不良预后无关。我们认为,在早期宫颈癌中,诊断性锥切术对后续的韦特海姆-梅格斯式根治性子宫切除术没有不利的负面影响。非根治性锥切术对预后没有影响。

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