Geldof A A, Becking J L, de Vries C D, van der Veen E A
Department of Endocrinology, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands.
In Vivo. 1992 Sep-Oct;6(5):545-51.
Histopathological changes in rat pancreas were induced by cyclic periods of experimental malnutrition or by cassava (manioc) feeding for 11 weeks. Decline of body weight was correlated with decrease in testicular fat pad weight as a measure of body fat stores. A marked decrease in pancreatic weight in the cassava-fed group was correlated with shrinkage of acinar structures and degenerative features in exocrine pancreas. In the malnutrition group vacuolisation and loss of tissue architecture were observed in some parts of the organ. No signs of ductal obstruction as a tentative cause of pancreatic pathology after malnutrition could be detected. Loss of islets tissue was occasionally seen in degenerative areas. It is concluded that histopathological changes in exocrine pancreas result from malnutrition and cassava feeding differentially and precede ultimate degenerative processes of pancreas endocrine tissue. Tropical malnutrition type diabetes and low protein related diabetes may in their etiology be different entities, but may coincide in practice and aggravate each other to yield severe and irreversible morbidity.
大鼠胰腺的组织病理学变化是由周期性实验性营养不良或喂食木薯（树薯）11周诱导产生的。体重下降与作为身体脂肪储存指标的睾丸脂肪垫重量减少相关。木薯喂养组胰腺重量显著下降，与腺泡结构萎缩和外分泌胰腺的退行性特征相关。在营养不良组中，在器官的某些部位观察到空泡化和组织结构丧失。未检测到营养不良后作为胰腺病理可能原因的导管阻塞迹象。在退行性区域偶尔可见胰岛组织丧失。结论是，外分泌胰腺的组织病理学变化分别由营养不良和木薯喂养引起，且先于胰腺内分泌组织的最终退行性过程。热带营养不良型糖尿病和低蛋白相关糖尿病在病因上可能是不同的实体，但在实际情况中可能同时出现并相互加重，导致严重且不可逆的发病情况。
