Kim Seung-Whan, Park Soojung, You Kwan-Hee, Kwon O-Yu
Department of Emergency Medicine, Chungnam National University Hospital, Taejon 301-721, Korea.
Z Naturforsch C J Biosci. 2003 Sep-Oct;58(9-10):736-9. doi: 10.1515/znc-2003-9-1025.
GRP94 (glucose regulated protein 94) gene expression in the ischemic-hippocampus of gerbils, which was induced by a temporary occlusion of the bilateral common carotid arteries (CCAs), was tested by Northern blot analysis. The maximum GRP94 gene expression level was detected at the occipital lobe 10 min after the induction of ischemia. In the hippocampus, GRP94 gene expression reached a maximum 15 min after inducing ischemia. Following reperfusion, the maximum expression level was shown at 12 h and continuing thereafter.
通过Northern印迹分析检测沙土鼠双侧颈总动脉（CCA）暂时闭塞诱导的缺血海马中GRP94（葡萄糖调节蛋白94）基因表达。缺血诱导后10分钟，在枕叶检测到GRP94基因表达的最高水平。在海马中，缺血诱导后15分钟GRP94基因表达达到最大值。再灌注后，最高表达水平出现在12小时并持续至此后。
