Ichikawa Y
First Department of Surgery, Yokohama City University School of Medicine, Japan.
ASAIO J. 1992 Jul-Sep;38(3):M266-70. doi: 10.1097/00002480-199207000-00034.
A new RV-PA conduit with a natural valve was developed using bovine jugular vein. To maintain the natural, mechanical properties of the veins, a hydrophilic cross-linking reagent, a glycerol polyglycidyl ether polyepoxy compound (PC) was used. The treatment has already been proven in the field of vascular grafts to be able to reduce antigenicity, biodegradability, and degenerative changes such as calcification, to induce antithrombogenicity with hydrogenicity, and to improve affinity to host cells. Bovine jugular veins were cross-linked with the reagent and were implanted as a conduit into the RV-PA position in six dogs. The main PA was ligated after implantation. One animal died due to bleeding 2 days after implantation; the other animals were healthy and allowed to survive until they were sacrificed. The graft was very soft and as pliable as native tissue, and was as strong as a heart valve. Post-operative catheterization and angiography showed adequate function of the valve. Macroscopic and microscopic observations revealed the antithrombogenicity of the graft in this animal study. These results indicated that this newly developed biologic valved conduit has a high probability of overcoming many problems observed in existing RV-PA conduits.
利用牛颈静脉研制出一种带有天然瓣膜的新型右心室-肺动脉管道。为保持静脉的天然机械性能，使用了一种亲水性交联试剂——甘油聚缩水甘油醚多环氧化合物（PC）。这种处理方法在血管移植物领域已被证明能够降低抗原性、生物降解性以及诸如钙化等退行性变化，通过亲水性诱导抗血栓形成，并提高与宿主细胞的亲和力。将牛颈静脉用该试剂交联后，作为管道植入6只狗的右心室-肺动脉位置。植入后结扎主肺动脉。1只动物在植入后2天因出血死亡；其他动物健康存活，直至被处死后进行解剖。该移植物非常柔软，柔韧性与天然组织一样，强度与心脏瓣膜相当。术后导管插入术和血管造影显示瓣膜功能良好。宏观和微观观察揭示了该移植物在本动物研究中的抗血栓形成特性。这些结果表明，这种新研制的生物带瓣管道极有可能克服现有右心室-肺动脉管道中观察到的许多问题。
