Pe'er Itsik, Beckmann Jacques S
Hum Genet. 2004 Jan;114(2):214-7. doi: 10.1007/s00439-003-1046-x. Epub 2003 Oct 25.
The rationale for mapping all common haplotypes in our species relies on reports of the conservation of haplotype blocks across human populations. Recent findings indicate that these blocks may, at least in part, be a random artifact of genetic drift. This raises the concern that the latter process may challenge the general applicability of a human haplotype map to case-by-case population-specific association studies. We develop arguments indicating that even stochastic drift-originated blocks will, under many conditions, be shared across populations, supporting the utilization of a panhuman haplotype map.
绘制我们人类所有常见单倍型图谱的基本原理，依赖于有关单倍型块在不同人群中具有保守性的报道。最近的研究结果表明，这些单倍型块可能至少部分是基因漂变的随机产物。这引发了人们的担忧，即后一过程可能会挑战人类单倍型图谱在针对特定人群的逐例关联研究中的普遍适用性。我们提出了一些观点，表明即使是起源于随机漂变的单倍型块，在许多情况下也会在不同人群中共享，这支持了泛人类单倍型图谱的应用。
