Yamada K, Onoda Y
Pharmacological Research Laboratory, Tanabe Seiyaku Co., Ltd.
J Smooth Muscle Res. 1992 Jun;28(3):87-93. doi: 10.1540/jsmr.28.87.
Effects of oral administration of trimebutine on colonic propulsion in conscious mice were studied by measuring the time required to evacuate a bead which had been inserted into the colon, and compared with those of metoclopramide and domperidone. In normal animals, trimebutine (10 and 50 mg/kg), metoclopramide (50 mg/kg) and domperidone (50 mg/kg) had no effect on the bead evacuation. Metoclopramide and domperidone at 30 mg/kg showed no effect on the delay of colonic propulsion induced by clonidine, while trimebutine (10 and 30 mg/kg) restored the delay significantly. Trimebutine also showed restoration of the delay induced by loperamide. On the acceleration of the propulsion induced by neostigmine, trimebutine (10 and 30 mg/kg) showed an inhibition. In addition, trimebutine (3-30 mg/kg) dose-dependently suppressed the development of soft feces and/or diarrhea induced by neostigmine. According to the results, it is concluded that trimebutine produces both acceleration and inhibition on the colonic propulsion in mice.
通过测量插入结肠的珠子排出所需时间，研究了口服曲美布汀对清醒小鼠结肠推进的影响，并与胃复安和多潘立酮进行了比较。在正常动物中，曲美布汀（10和50mg/kg）、胃复安（50mg/kg）和多潘立酮（50mg/kg）对珠子排出没有影响。30mg/kg的胃复安和多潘立酮对可乐定引起的结肠推进延迟没有影响，而曲美布汀（10和30mg/kg）能显著恢复延迟。曲美布汀还能恢复洛哌丁胺引起的延迟。在新斯的明引起的推进加速方面，曲美布汀（10和30mg/kg）表现出抑制作用。此外，曲美布汀（3 - 30mg/kg）剂量依赖性地抑制了新斯的明引起的软便和/或腹泻的发生。根据结果得出结论，曲美布汀对小鼠结肠推进既有加速作用又有抑制作用。
