Tardio-Dovao J, Escalona-Zapata J, Diez-Nau M D
Department of Pathology, General Hospital Gregorio Marañón, Madrid, Spain.
Histol Histopathol. 1992 Oct;7(4):611-7.
Liposarcoma falls into the differential diagnosis of myxoid malignant mesenchymal tumors. On the other hand, its relation with white or brown fat is controversial. Two cases of liposarcoma have been studied by organ culture, a method which provides cell and tissue redifferentiation in vitro. Both cases developed successively cytoplasmic glycogen granules and lipid droplets as well as a single lipidic vacuole in the late phase of cultivation as a marker of fat differentiation. Our results support the possibility of identifying myxoid liposarcomas as well as their origin from white fat tissue.
脂肪肉瘤属于黏液样恶性间充质肿瘤的鉴别诊断范畴。另一方面，它与白色或棕色脂肪的关系存在争议。通过器官培养对两例脂肪肉瘤进行了研究，器官培养是一种能在体外实现细胞和组织再分化的方法。在培养后期，两例病例均相继出现细胞质糖原颗粒、脂滴以及单个脂质空泡，作为脂肪分化的标志。我们的结果支持将黏液样脂肪肉瘤鉴定出来以及其起源于白色脂肪组织的可能性。
