Friedman D I
University of Michigan, Ann Arbor.
Curr Opin Genet Dev. 1992 Oct;2(5):727-38. doi: 10.1016/s0959-437x(05)80133-9.
Bacteriophage lambda relies to a large extent on processes requiring interactions between viral- and host-encoded proteins for its lytic growth, establishment of lysogeny, and release from the prophage state. Both biochemical and genetic studies of these interactions have yielded new information about important host and lambda functions. In particular, mutations in Escherichia coli that compromise lambda DNA replication, genome packaging, transcription elongation, and site-specific recombination have led to the identification of bacterial genes whose products are chaperones, transcription factors, or DNA-binding proteins.
噬菌体λ在很大程度上依赖于病毒编码蛋白与宿主编码蛋白之间相互作用的过程来实现其裂解生长、溶原性建立以及从原噬菌体状态释放。对这些相互作用的生化和遗传学研究均产生了关于重要宿主和λ功能的新信息。特别是，大肠杆菌中影响λDNA复制、基因组包装、转录延伸和位点特异性重组的突变，已导致鉴定出其产物为伴侣蛋白、转录因子或DNA结合蛋白的细菌基因。
