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基本细胞周期所需的专用功能的最小数量是多少?

What is the minimum number of dedicated functions required for a basic cell cycle?

作者信息

Donachie W D

机构信息

Institute of Cell and Molecular Biology, University of Edinburgh, Scotland.

出版信息

Curr Opin Genet Dev. 1992 Oct;2(5):792-8. doi: 10.1016/s0959-437x(05)80141-8.

Abstract

The genome of Escherichia coli has a coding capacity for about 4500 proteins but only a small number of these appear to be specific for the periodic events (initiation of DNA replication, chromosome partitioning and cell division) that punctuate the cell-duplication cycle: furthermore, many of these cell cycle dedicated functions are dispensible under certain conditions, although their presence undoubtedly increases the fitness of the organism to survive in a competitive environment. A simplified but effective cell replication cycle can probably operate with only a few cycle-dedicated proteins, in addition to those required for cell growth itself.

摘要

大肠杆菌的基因组具有编码约4500种蛋白质的能力,但其中只有少数似乎是细胞复制周期中周期性事件(DNA复制起始、染色体分离和细胞分裂)所特有的:此外,许多这些细胞周期专用功能在某些条件下是可有可无的,尽管它们的存在无疑会提高生物体在竞争环境中生存的适应性。除了细胞生长本身所需的蛋白质外,一个简化但有效的细胞复制周期可能仅靠少数细胞周期专用蛋白质就能运行。

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