为肿瘤坏死因子信号传导增添新视角。JNK视角。
Adding facets to TNF signaling. The JNK angle.
作者信息
Liu Zheng-gang
机构信息
Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Mol Cell. 2003 Oct;12(4):795-6. doi: 10.1016/s1097-2765(03)00399-x.
Abstract
In the October 3 issue of Cell, Deng et al. (2003) report that a JNK-dependent mitochondrial signal, the release of Smac/DIABLO, is required for TNF-induced caspase 8 activation and apoptosis. This process is interceded by a novel processed form of the BH3 only protein Bid.
摘要
邓等人在10月3日的《细胞》杂志上发表报告称，肿瘤坏死因子（TNF）诱导的半胱天冬酶8激活及细胞凋亡需要一种由JNK（应激活化蛋白激酶）依赖的线粒体信号，即Smac/DIABLO的释放。这一过程由仅含BH3结构域的蛋白质Bid的一种新加工形式介导。
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