通过1H-13C固态核磁共振光谱法测量微晶状CRH中的水-蛋白质相互作用。
Water-protein interactions in microcrystalline crh measured by 1H-13C solid-state NMR spectroscopy.
作者信息
Lesage Anne, Böckmann Anja
机构信息
Laboratoire de Chimie, UMR 5532 CNRS-ENS, Ecole Normale Supérieure de Lyon, 46, allée d'Italie, 69364 Lyon, France.
出版信息
J Am Chem Soc. 2003 Nov 5;125(44):13336-7. doi: 10.1021/ja036720y.
PMID:14583011
Abstract
Using solid-state NMR carbon-proton dipolar correlation spectroscopy, we observed hydrogen exchange on the millisecond time scale between water molecules and protein protons in a solid sample. These interactions are shown to be related to important structural features of the protein such as hydrogen-bonding or salt-bridge networks.
摘要
通过固态核磁共振碳-质子偶极相关光谱法，我们在一个固体样品中观察到了水分子与蛋白质质子之间在毫秒时间尺度上的氢交换。这些相互作用被证明与蛋白质的重要结构特征有关，如氢键或盐桥网络。
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