Kok M R, Baum B J, Tak P P, Pillemer S R
Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
Ann Rheum Dis. 2003 Nov;62(11):1038-46. doi: 10.1136/ard.62.11.1038.
Effective treatment for Sjögren's syndrome (SS) might be developed locally by introducing genes encoding cytokines, which are potentially anti-inflammatory, or by introducing a cDNA encoding a soluble form of a key cytokine receptor, which can act as an antagonist and decrease the availability of certain cytokines, such as soluble tumour necrosis factor alpha receptors. Currently, the preferred choice of viral vector for immunomodulatory gene transfer is recombinant adeno-associated virus. The use of gene transfer to help determine the pathophysiology and to alter the course of the SS-like disease in the NOD mouse model can ultimately lead to the development of new treatments for managing the salivary component in patients with SS.
通过引入编码具有潜在抗炎作用的细胞因子的基因,或引入编码关键细胞因子受体可溶性形式的cDNA(其可作为拮抗剂并降低某些细胞因子如可溶性肿瘤坏死因子α受体的可用性),可能在局部开发出针对干燥综合征(SS)的有效治疗方法。目前,用于免疫调节基因转移的病毒载体的首选是重组腺相关病毒。利用基因转移来帮助确定病理生理学并改变NOD小鼠模型中类干燥综合征疾病的进程,最终可能会开发出用于治疗SS患者唾液成分的新疗法。