Gillies D, O'Riordan L, Carr D, Frost J, Gunning R, O'Brien I
School of Nursing, Family and Community Health, College of Social and Health Sciences, University of Western Sydney,Parramatta Campus, Building ER, Locked Bag 1797, Penrith South DC, New South Wales, Australia, NSW 1797.
Cochrane Database Syst Rev. 2003(4):CD003827. doi: 10.1002/14651858.CD003827.
Central venous catheters facilitate venous access, allowing the intravenous administration of complex drug treatments, blood products and nutritional support, without the trauma associated with repeated venepuncture. However, central venous catheters are associated with a risk of infection. Some studies have indicated that the type of dressing used for central venous catheters may affect the risk of infection. Gauze and tape or transparent polyurethane film dressings such as Tegaderm, Opsite or Opsite IV3000 are the most common types of dressing used to secure central venous catheters. Currently, it is not clear which type of dressing is the most appropriate.
To compare gauze and tape and transparent polyurethane central venous catheter dressings in terms of catheter related infection, catheter security, tolerance to dressing material and dressing condition in hospitalised adults and children.
The Cochrane Wounds Group Specialised Trials Register (October 2002), the Cochrane Controlled Trials Register (4th Quarter 2002) and the databases; MEDLINE (1966-December 2002, CINAHL (1982-October 2002) and EMBASE (1980-December 2002) were searched to identify any randomised controlled trials comparing the effects of gauze and tape and/or transparent polyurethane dressings for central venous catheter sites. Additional references were identified from bibliographies of published literature and were also sought from other sources.
All randomised controlled trials evaluating the effects of dressing type (i.e. gauze and tape and/or transparent polyurethane dressings) on central venous catheter related infection, catheter security, tolerance to dressing material and dressing condition in hospitalised patients.
Twenty-three studies were reviewed. Data was extracted from each paper by two members of the review team independently and results then compared. Differences were resolved either by consensus or by referral to a third member of the review team. Authors were contacted for missing information.
Of the 23 studies reviewed, 14 were excluded. Nine studies were included. Data was only available for meta-analysis from six of the nine included studies. Of the six included studies with available data, two compared gauze and tape with Opsite IV3000, two compared Opsite with Opsite IV3000, one compared gauze and tape with Tegaderm, and one compared Tegaderm with Opsite. There was no evidence of any difference in the incidence of infectious complications between any of the dressing types compared in this review. Each of these comparisons was based on no more than two studies and all of these studies reported data from a small patient sample. Therefore it is probable that the finding of no difference between dressing types is due to the lack of adequate data.
REVIEWER'S CONCLUSIONS: There is a high level of uncertainty regarding the risk of infection with the central venous catheter dressings identified in this review. Therefore, at this stage it appears that the choice of dressing for central venous catheters can be based on patient preference. To identify the most appropriate central venous catheter dressings, further research is necessary. It is paramount that any future studies investigating this issue must be rigorously performed randomised controlled trials.
中心静脉导管便于静脉穿刺,可用于静脉输注复杂药物治疗、血液制品及营养支持,且避免了反复静脉穿刺带来的创伤。然而,中心静脉导管存在感染风险。一些研究表明,用于中心静脉导管的敷料类型可能会影响感染风险。纱布和胶带或透明聚氨酯薄膜敷料(如泰德思、欧皮贴或欧皮贴IV3000)是固定中心静脉导管最常用的敷料类型。目前,尚不清楚哪种敷料最为合适。
比较纱布和胶带与透明聚氨酯中心静脉导管敷料在住院成人和儿童中与导管相关感染、导管固定安全性、对敷料材料的耐受性及敷料状况方面的差异。
检索了考克兰伤口组专业试验注册库(2002年10月)、考克兰对照试验注册库(2002年第4季度)以及MEDLINE(1966年 - 2002年12月)、CINAHL(1982年 - 2002年10月)和EMBASE(1980年 - 2002年12月)数据库,以识别比较纱布和胶带及/或透明聚氨酯敷料用于中心静脉导管部位效果的随机对照试验。从已发表文献的参考文献中识别了其他参考文献,并从其他来源进行了查找。
所有评估敷料类型(即纱布和胶带及/或透明聚氨酯敷料)对住院患者中心静脉导管相关感染、导管固定安全性、对敷料材料的耐受性及敷料状况影响的随机对照试验。
对23项研究进行了综述。由综述团队的两名成员独立从每篇论文中提取数据,然后比较结果。差异通过协商解决或转交给综述团队的第三名成员。联系作者获取缺失信息。
在综述的23项研究中,排除了14项。纳入了9项研究。仅9项纳入研究中的6项有数据可用于荟萃分析。在6项有可用数据的纳入研究中,2项比较了纱布和胶带与欧皮贴IV3000,2项比较了欧皮贴与欧皮贴IV3000,1项比较了纱布和胶带与泰德思,1项比较了泰德思与欧皮贴。本综述中比较的任何敷料类型之间,均无证据表明感染并发症发生率存在差异。这些比较中的每一项均基于不超过两项研究,且所有这些研究报告的患者样本量都较小。因此,敷料类型之间无差异的发现可能是由于缺乏足够的数据。
本综述中确定的中心静脉导管敷料的感染风险存在高度不确定性。因此,现阶段中心静脉导管敷料的选择似乎可基于患者偏好。为确定最合适的中心静脉导管敷料,有必要进行进一步研究。至关重要的是,未来任何研究此问题的研究都必须严格进行随机对照试验。