Kähkönen Seppo, Zvartau Edwin E
BioMag Laboratory, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
Neuropsychobiology. 2003;48(3):124-30. doi: 10.1159/000073628.
The cardiovascular effects and pharmacokinetics of a single dose (20 mg sublingually) of isosorbide dinitrate (ISDN) were studied in 9 alcohol-dependent men during alcohol withdrawal syndrome (AW) on day 1 and after the resolution of AW on day 10. At the onset of AW, ISDN and its metabolites caused a hypotensive effect, which was increased on day 10, while no differences in ISDN-induced decrease in stroke volume were observed. Tachycardiac response to ISDN was more pronounced at onset of AW. On day 10, the AUC(0-1.5 h), C(max) and t((1/2)) of ISDN were increased compared with day 1. The results of this study suggest that nitric oxide may modulate the cardiovascular system in AW.
在9名酒精依赖男性中，研究了单剂量（舌下含服20毫克）硝酸异山梨酯（ISDN）在戒酒综合征（AW）第1天和第10天AW消退后的心血管效应和药代动力学。在AW开始时，ISDN及其代谢产物引起降压作用，在第10天增强，而在ISDN引起的每搏输出量减少方面未观察到差异。在AW开始时，对ISDN的心动过速反应更明显。与第1天相比，第10天ISDN的AUC(0-1.5 h)、C(max)和t((1/2))增加。本研究结果表明，一氧化氮可能在AW中调节心血管系统。
