De Benedetti F, Robbioni P, Massa M, Viola S, Albani S, Martini A
Università di Pavia, I.R.C.C.S. Policlinico, S. Matteo, Italy.
Clin Exp Rheumatol. 1992 Sep-Oct;10(5):493-8.
We measured serum and synovial fluid interleukin 6 (IL-6) levels in patients with polyarticular-onset and pauciarticular-onset juvenile chronic arthritis (JCA), using the hybridoma cell line B9. During active disease, but not during remission, serum IL-6 levels were significantly elevated in patients with polyarticular (p < 0.0001 vs controls) and in patients with pauciarticular JCA (p < 0.01 vs controls). In patients with active polyarticular disease (polyarticular and extended pauciarticular) serum IL-6 levels correlated with the extent and severity of joint involvement (p < 0.05), with erythrocyte sedimentation rate values (p < 0.005) and with C reactive protein concentrations (p < 0.05). In patients with persistent pauciarticular JCA, serum IL-6 levels correlated with the joint swelling score (p < 0.05). Synovial fluid IL-6 levels, measured in 5 patients with pauciarticular JCA, were markedly elevated (range 600-24,000 HGF U/ml). In conclusion, our data suggest that IL-6 is an important pathogenic mediator in polyarticular and pauciarticular JCA.
我们使用杂交瘤细胞系B9检测了多关节起病型和少关节起病型青少年慢性关节炎（JCA）患者的血清和滑液白细胞介素6（IL-6）水平。在疾病活动期而非缓解期，多关节型患者（与对照组相比，p < 0.0001）和少关节型JCA患者（与对照组相比，p < 0.01）的血清IL-6水平显著升高。在活动期多关节疾病患者（多关节型和扩展性少关节型）中，血清IL-6水平与关节受累的范围和严重程度相关（p < 0.05），与红细胞沉降率值相关（p < 0.005），与C反应蛋白浓度相关（p < 0.05）。在持续性少关节型JCA患者中，血清IL-6水平与关节肿胀评分相关（p < 0.05）。在5例少关节型JCA患者中检测的滑液IL-6水平显著升高（范围为600 - 24,000 HGF U/ml）。总之，我们的数据表明IL-6是多关节型和少关节型JCA中的一种重要致病介质。
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