Uchiyama F, Fukuyama J, Kamei T
Uchiyama Clinic, Chigasaki Tokushukai Medical Center.
Rinsho Shinkeigaku. 1992 May;32(5):547-9.
A 74-year-old male presented with a total loss of taste of ten weeks' duration. He could not recognize both saturated sugar and salt solutions but his acuity for smell was normal. He also had a slight hoarseness, mild dysarthria and hyporeflexia of all extremities. Laboratory data revealed marked hypothyroidism and positive tests for antithyroglobulin and antimicrosomal antibodies. Shortly after the institution of thyroxine replacement, subjective response in taste acuity was seen. Almost complete recovery of taste followed after a month of incremental dose of thyroxine. The case indicates that thyroid hormones play a significant role in taste acuity. Hypothyroidism should be considered as one of the possible causes in taste defect.
一名74岁男性出现味觉完全丧失,持续了十周。他无法辨别饱和糖溶液和盐溶液,但嗅觉正常。他还伴有轻微声音嘶哑、轻度构音障碍以及四肢反射减弱。实验室检查显示明显的甲状腺功能减退,抗甲状腺球蛋白和抗微粒体抗体检测呈阳性。在开始使用甲状腺素替代治疗后不久,味觉敏锐度出现了主观改善。在甲状腺素剂量递增一个月后,味觉几乎完全恢复。该病例表明甲状腺激素在味觉敏锐度方面起着重要作用。甲状腺功能减退应被视为味觉缺陷的可能原因之一。