通过（RS）-5-叔丁基环戊烯-1-羧酸甲酯的平行动力学拆分制备（1R，2S，5S）-和（1S，2R，5R）-2-氨基-5-叔丁基环戊烷-1-羧酸甲酯
Preparation of methyl (1R,2S,5S)- and (1S,2R,5R)-2-amino-5-tert-butyl-cyclopentane-1-carboxylates by parallel kinetic resolution of methyl (RS)-5-tert-butyl-cyclopentene-1-carboxylate.
作者信息
Davies Stephen G, Díez David, El Hammouni Mohamed M, Garner A Christopher, Garrido Narciso M, Long Marcus J C, Morrison Rachel M, Smith Andrew D, Sweet Miles J, Withey Jonathan M
机构信息
The Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, UK OX1 3QY.
出版信息
Chem Commun (Camb). 2003 Oct 7(19):2410-1. doi: 10.1039/b308855c.
DOI:10.1039/b308855c
PMID:14587706
Abstract
Comparison of the kinetic and parallel kinetic resolutions of methyl (RS)-5-tert-butyl-cyclopentene-1-carboxylate allows for the efficient synthesis of both (1R,2S,5S)- and (1S,2R,5R)-enantiomers of methyl 2-amino-5-tert-butyl-cyclopentane-1-carboxylate.
摘要
（RS）-5-叔丁基-环戊烯-1-羧酸甲酯的动力学拆分和平行动力学拆分的比较，使得2-氨基-5-叔丁基-环戊烷-1-羧酸甲酯的（1R，2S，5S）-和（1S，2R，5R）-对映体都能高效合成。
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