骨细胞。

The osteocyte.

作者信息

Knothe Tate Melissa L, Adamson Josée R, Tami Andrea E, Bauer Thomas W

机构信息

Orthopaedic Research Center, The Cleveland Clinic, 44195, Cleveland, OH, USA.

出版信息

Int J Biochem Cell Biol. 2004 Jan;36(1):1-8. doi: 10.1016/s1357-2725(03)00241-3.

DOI:10.1016/s1357-2725(03)00241-3

PMID:14592527

Abstract

Osteocytes are the most numerous cells in mature bone and have the potential to live as long as the organism itself. However, study and subsequent understanding of osteocyte biology has been thwarted by the remote location of the cell in the mineralized matrix. This review is intended to synthesize current understanding of osteocyte biology and to suggest future paths that will promote understanding of this obscure cell and translation of knowledge to disease prophylaxis and management.

摘要

骨细胞是成熟骨骼中数量最多的细胞，并且有可能与生物体本身存活的时间一样长。然而，对骨细胞生物学的研究以及后续的理解一直受到该细胞在矿化基质中所处偏远位置的阻碍。本综述旨在综合当前对骨细胞生物学的理解，并提出未来的研究方向，以促进对这种难以捉摸的细胞的理解，并将相关知识转化为疾病的预防和管理。