Nefussi J R, Sautier J M, Nicolas V, Forest N
Laboratoire de Biologie-Odontologie, Université Paris VII, Paris, France.
J Biol Buccale. 1991 Mar;19(1):75-82.
Osteocyte matrix inclusion process was studied in an in vitro woven bone nodule formation model where a large number of osteocytes at different degrees of maturation were examined. This work focused on early stages of osteocyte inclusion. This matrix inclusion occurred without a matrix synthesis inversion by the future osteocyte and with maintenance of close cell contacts with the replacing cell. A passive matrix embedding process related to a decreased activity of the osteoblast-osteocyte cell is proposed as a comprehensive pathway from osteoblast to osteocyte. The formation of the osteocyte is therefore presented as a very coordinated space and time related cell-cell interaction between cells of the three cell pools of the bone.
在体外编织骨结节形成模型中研究了骨细胞基质包埋过程，该模型中检测了大量不同成熟度的骨细胞。这项工作聚焦于骨细胞包埋的早期阶段。这种基质包埋发生时，未来的骨细胞不会出现基质合成反转，并且与替代细胞保持紧密的细胞接触。有人提出，与成骨细胞-骨细胞活性降低相关的被动基质嵌入过程是从成骨细胞到骨细胞的综合途径。因此，骨细胞的形成表现为骨的三个细胞池中的细胞之间非常协调的与空间和时间相关的细胞-细胞相互作用。
