Bonnemaison E, Lanotte Ph, Cantagrel S, Thionois S, Quentin R, Chamboux C, Laugier J
Groupement de réanimation et de médecine néonatale, Hôpital de Clocheville, Tours, France.
Biol Neonate. 2003;84(4):304-10. doi: 10.1159/000073639.
Two protocols are used by French neonatologists for the treatment of suspected maternofetal infection (SMFI). Three groups of premature and term neonates were included to study the impact of antibiotics on fecal flora: 10 infants with SMFI treated with amoxicillin and netilmicin (group BI), 10 infants with SMFI treated with amoxicillin, cefotoxime and netilmicin (group TRI) and 10 infants without antibiotic therapy as controls (group C). Group BI samples were colonized with Klebsiella oxytoca and Escherichia coli resistant to amoxicillin and by Eneterococcus faecium and coagulase-negative staphylococci. In group TRI biodiversity of the intestinal flora was low, with rapid growth of staphyloccoci and occurrence of Candida spp. These modifications of the intestinal flora should encourage us to use antibiotic treatment as targeted as possible.
法国新生儿科医生采用两种方案治疗疑似母婴感染（SMFI）。研究抗生素对粪便菌群的影响时纳入了三组早产儿和足月儿：10例患有SMFI且接受阿莫西林和奈替米星治疗的婴儿（BI组），10例患有SMFI且接受阿莫西林、头孢噻肟和奈替米星治疗的婴儿（TRI组），以及10例未接受抗生素治疗的婴儿作为对照组（C组）。BI组样本被产酸克雷伯菌和对阿莫西林耐药的大肠杆菌以及粪肠球菌和凝固酶阴性葡萄球菌定植。TRI组肠道菌群的生物多样性较低，葡萄球菌快速生长且念珠菌属出现。肠道菌群的这些变化应促使我们尽可能有针对性地使用抗生素治疗。
