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孕期应激暴露会改变恒河猴幼崽在新奇刺激条件下的产后行为表现。

Prenatal stress exposure alters postnatal behavioral expression under conditions of novelty challenge in rhesus monkey infants.

作者信息

Schneider M L

机构信息

Department of Therapeutic Science, University of Wisconsin, Madison 53706-1532.

出版信息

Dev Psychobiol. 1992 Nov;25(7):529-40. doi: 10.1002/dev.420250706.

DOI:10.1002/dev.420250706
PMID:1459346
Abstract

This prospective study investigated whether mild maternal stress during pregnancy could alter the behavioral and affective responses in rhesus monkey infants in a complex, novel environment. Twenty-four rhesus monkey infants were tested on three occasions at 6 months of age in a novel environment. Twelve infants were derived from mothers exposed to a daily 10-min mild stressor from Day 90 to Day 145 postconception, while 12 were derived from mothers undisturbed during pregnancy. Prenatally stressed infants demonstrated more disturbance behavior, and lower levels of gross motor/exploratory behavior. Moreover, half of the prenatally stressed infants showed an abnormal response, falling asleep, while none of the control infants displayed this behavior. Males exhibited more clinging to surrogates, while females spent more time in gross motor/exploratory behaviors, with prenatally stressed males tending to spend the least time in gross motor/exploratory activity.

摘要

这项前瞻性研究调查了孕期母亲轻度应激是否会改变恒河猴幼崽在复杂新奇环境中的行为和情感反应。24只恒河猴幼崽在6个月大时于新奇环境中接受了三次测试。12只幼崽的母亲在受孕后第90天至第145天每天暴露于10分钟的轻度应激源,而另外12只幼崽的母亲在孕期未受干扰。产前应激的幼崽表现出更多的干扰行为,以及较低水平的大肌肉运动/探索行为。此外,一半产前应激的幼崽表现出异常反应,即入睡,而对照幼崽中无一表现出这种行为。雄性表现出更多地依附替代物,而雌性则在大肌肉运动/探索行为上花费更多时间,产前应激的雄性在大肌肉运动/探索活动上花费的时间往往最少。

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