母孕期皮质醇程序化胎儿下丘脑-垂体-肾上腺轴。
Maternal prenatal cortisol programs the infant hypothalamic-pituitary-adrenal axis.
机构信息
Department of Psychology, University of La Verne, La Verne, CA 91750, United States; Department of Psychology, Chapman University, Orange, CA 92866, United States.
Department of Psychology, University of Denver, Denver, CO 80208, United States.
出版信息
Psychoneuroendocrinology. 2021 Mar;125:105106. doi: 10.1016/j.psyneuen.2020.105106. Epub 2020 Dec 11.
Abstract
One of the key proposed agents of fetal programming is exposure to maternal glucocorticoids. Experimental animal studies provide evidence that prenatal exposure to elevated maternal glucocorticoids has consequences for hypothalamic-pituitary-adrenal (HPA) axis functioning in the offspring. There are very few direct tests of maternal glucocorticoids, such as cortisol, during human pregnancy and associations with infant cortisol reactivity. The current study examined the link between maternal prenatal cortisol trajectories and infant cortisol reactivity to the pain of inoculation in a sample of 152 mother-infant (47.4% girls) pairs. The results from the current study provide insight into fetal programming of the infant HPA axis, demonstrating that elevated prenatal maternal cortisol is associated with a larger infant cortisol response to challenge at both 6 and 12 months of age.
摘要
其中一个胎儿编程的关键提出的代理是暴露于母亲的糖皮质激素。实验动物研究提供的证据表明，产前暴露于升高的母源性糖皮质激素对后代的下丘脑-垂体-肾上腺（HPA）轴功能有影响。有很少的直接测试的母源性糖皮质激素，如皮质醇，在人类怀孕期间和与婴儿皮质醇反应性的关联。本研究在 152 对母婴（47.4%的女孩）样本中，考察了母亲产前皮质醇轨迹与婴儿接种疼痛时皮质醇反应性之间的联系。本研究的结果提供了对婴儿 HPA 轴胎儿编程的深入了解，表明产前母体皮质醇升高与 6 个月和 12 个月大的婴儿对挑战的皮质醇反应更大有关。
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