孕期服用双膦酸盐类药物。
Taking bisphosphonates during pregnancy.
作者信息
French Amy E, Kaplan Nikolay, Lishner Michael, Koren Gideon
机构信息
Motherisk Team, Hospital for Sick Children in Toronto, Ont.
出版信息
Can Fam Physician. 2003 Oct;49:1281-2.
Abstract
QUESTION
Several of my female patients take bisphosphonates for low bone mineral density (BMD). Two of them are of reproductive age. Are these drugs safe during pregnancy?
ANSWER
Very little is currently known about the effects of bisphosphonates on human pregnancy. There have been only two reports of bisphosphonate use during late pregnancy. Animal studies suggest that biphosphonates cross the placenta and that the effect is an extension of the expected pharmacologic effect of bisphosphonates on both fetus and mother. Risks and benefits should be carefully weighed.
摘要
问题
我的几位女性患者因骨矿物质密度（BMD）低而服用双膦酸盐。其中两位处于育龄期。这些药物在孕期安全吗？
答案
目前对于双膦酸盐对人类妊娠的影响知之甚少。仅有两份关于妊娠晚期使用双膦酸盐的报告。动物研究表明双膦酸盐可穿过胎盘，其作用是双膦酸盐对胎儿和母亲预期药理作用的延伸。应仔细权衡风险和益处。
相似文献
1
Taking bisphosphonates during pregnancy.
Can Fam Physician. 2003 Oct;49:1281-2.
2
Pregnancy outcome following in utero exposure to bisphosphonates.
Bone. 2009 Mar;44(3):428-30. doi: 10.1016/j.bone.2008.11.001. Epub 2008 Nov 14.
3
Does treatment with bisphosphonates endanger the human pregnancy?
J Obstet Gynaecol Can. 2008 Dec;30(12):1146-1148. doi: 10.1016/S1701-2163(16)34026-9.
4
Bisphosphonates in the prevention and treatment of glucocorticoid-induced osteoporosis.
J Fam Pract. 2000 Sep;49(9):839-48.
5
Bisphosphonates in chronic kidney disease; balancing potential benefits and adverse effects on bone and soft tissue.
Clin J Am Soc Nephrol. 2009 Jan;4(1):221-33. doi: 10.2215/CJN.02550508. Epub 2008 Nov 5.
6
7
Transplacental effects of bisphosphonates on fetal skeletal ossification and mineralization in rats.
Teratology. 1999 Aug;60(2):68-73. doi: 10.1002/(SICI)1096-9926(199908)60:2<68::AID-TERA10>3.0.CO;2-H.
8
Additive effects of PTH and bisphosphonates on the bone healing response to metaphyseal implants in rats.
Acta Orthop. 2008 Feb;79(1):111-5. doi: 10.1080/17453670710014851.
9
Effect of bisphosphonate treatment on bone mineral density in patients with thalassaemia major.
Pediatr Endocrinol Rev. 2008 Oct;6 Suppl 1:144-8.
10
[Minodronic acid hydrate as a new therapeutic agent for osteoporosis].
Clin Calcium. 2005 Jan;15(1):9-14.
引用本文的文献
1
Evidence based Latin American Guidelines of clinical practice on prevention, diagnosis, management and treatment of glucocorticoid induced osteoporosis. A 2022 update : This manuscript has been produced under the auspices of the Committee of National Societies (CNS) and the Committee of Scientific Advisors (CSA) of the International Osteoporosis Foundation (IOF).
Aging Clin Exp Res. 2022 Nov;34(11):2591-2602. doi: 10.1007/s40520-022-02261-2. Epub 2022 Nov 9.
2
Aggressive giant cell tumour (GCT) of the distal humerus in a young pregnant woman.
BMJ Case Rep. 2022 Feb 9;15(2):e246001. doi: 10.1136/bcr-2021-246001.
3
Guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis: an update of Brazilian Society of Rheumatology (2020).
Arch Osteoporos. 2021 Mar 1;16(1):49. doi: 10.1007/s11657-021-00902-z.
4
Seventeen Cases of Primary Hyperparathyroidism in Pregnancy: A Call for Management Guidelines.
J Endocr Soc. 2019 Feb 20;3(5):1009-1021. doi: 10.1210/js.2018-00340. eCollection 2019 May 1.
5
Theobromine Upregulates Osteogenesis by Human Mesenchymal Stem Cells In Vitro and Accelerates Bone Development in Rats.
Calcif Tissue Int. 2017 Mar;100(3):298-310. doi: 10.1007/s00223-016-0215-6. Epub 2016 Dec 2.
6
Transient osteoporosis associated with pregnancy: use of bisphosphonate in treating a lactating mother.
BMJ Case Rep. 2010 Dec 14;2010:bcr0720092112. doi: 10.1136/bcr.07.2009.2112.
本文引用的文献
1
Intravenous pamidronate for treatment of reflex sympathetic dystrophy during breast feeding.
J Bone Miner Res. 2000 Oct;15(10):2052-5. doi: 10.1359/jbmr.2000.15.10.2052.
2
Transplacental effects of bisphosphonates on fetal skeletal ossification and mineralization in rats.
Teratology. 1999 Aug;60(2):68-73. doi: 10.1002/(SICI)1096-9926(199908)60:2<68::AID-TERA10>3.0.CO;2-H.
3
Malignant hypercalcaemia in pregnancy and antenatal administration of intravenous pamidronate.
Clin Oncol (R Coll Radiol). 1996;8(4):257-8. doi: 10.1016/s0936-6555(05)80667-3.
4
Effects of the bisphosphonate, alendronate, on parturition in the rat.
Toxicol Appl Pharmacol. 1993 Aug;121(2):217-23. doi: 10.1006/taap.1993.1148.
5
Intravenous reproductive and developmental toxicity studies of cimadronate (YM175), a novel bisphosphonate, in rats and rabbits.
J Toxicol Sci. 1995 Oct;20 Suppl 1:1-13. doi: 10.2131/jts.20.supplementi_1.
6
The effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) on fetal mice during pregnancy--with emphasis on implantation and fetal weight.
J Osaka Dent Univ. 1986 Oct;19(2):87-90.
7
Antenatal administration of aminopropylidene diphosphonate.
Ann Rheum Dis. 1990 Nov;49(11):955. doi: 10.1136/ard.49.11.955-a.
8
Reproduction toxicity studies with pamidronate.
Arzneimittelforschung. 1992 May;42(5):654-67.
Zotero 插件