Jatoi Ismail
Department of Surgery, US Army Hospital Heidelberg, Heidelberg, Germany.
Curr Med Res Opin. 2003;19(6):567-9. doi: 10.1185/030079903125002207.
For over a century, there has been considerable interest in the management of regional lymph node metastasis in patients with primary breast cancer. Since the advent of sentinel lymph node biopsies, there has been renewed interest in the management of patients with metastasis to the internal mammary nodes. The appropriate management of these patients has not yet been established. Some investigators propose that biopsy of the internal mammary sentinel node may provide additional prognostic information which might be used to guide the administration of systemic adjuvant therapy. Additionally, it has been suggested that patients with metastasis to the internal mammary sentinel node may benefit from radiotherapy to the internal mammary nodal chain. Clinical trials are needed to resolve these issues. Internal mammary sentinel node biopsy in patients with primary breast cancer should be considered investigational, and conducted only in the context of clinical trials.
一个多世纪以来，原发性乳腺癌患者区域淋巴结转移的管理一直备受关注。自前哨淋巴结活检问世以来，人们对乳腺内淋巴结转移患者的管理重新产生了兴趣。这些患者的恰当管理方式尚未确立。一些研究人员提出，乳腺内前哨淋巴结活检可能会提供额外的预后信息，可用于指导全身辅助治疗的实施。此外，有人认为乳腺内前哨淋巴结转移的患者可能从乳腺内淋巴结链放疗中获益。需要进行临床试验来解决这些问题。原发性乳腺癌患者的乳腺内前哨淋巴结活检应被视为试验性操作，且仅应在临床试验的背景下进行。
